We work on mechanisms of aging so that people lead healthier lives.
Why do living things age? What genes influence longevity? Is it possible to extend youthfulness by means of genetic manipulation? Our research analyzes these tantalizing questions and others in molecular detail.
For an engaging discussion of the lab’s history, see Dr. Guarente’s book Ageless Quest: One Scientist’s Search for Genes That Prolong Youth.
Based on the discovery that SIR2 is a key regulator of longevity in both yeast and worms, we are interested in determining whether this highly-conserved gene also governs longevity in mammals.