PUBLICATIONS

Search PubMed for GuarenteLab Publications
Search EBSCOhost for GuarenteLab Publications
Dr. Leonard P. Guarente | Principal Investigator
  1. Holmes HE, Valentin RE, Jernerén F, de Jager Loots CA, Refsum H, Smith AD, Guarente L, Dellinger RW, Sampson D; Alzheimer’s Disease Neuroimaging Initiative. Elevated homocysteine is associated with increased rates of epigenetic aging in a population with mild cognitive impairment. Aging Cell. 2024 Oct;23(10):e14255. doi: 10.1111/acel.14255. Epub 2024 Jun 27. PMID: 38937999; PMCID: PMC11464110.
  2. Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA. Correction: The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth. PLoS One. 2024 Jun 6;19(6):e0305277. doi: 10.1371/journal.pone.0305277. Erratum for: PLoS One. 2008 Apr 16;3(4):e2020. doi: 10.1371/journal.pone.0002020. PMID: 38843127; PMCID: PMC11156279.
  3. Guarente L, Sinclair DA, Kroemer G. Human trials exploring anti-aging medicines. Cell Metab. 2024 Feb 6;36(2):354-376. doi: 10.1016/j.cmet.2023.12.007. Epub 2024 Jan 4. PMID: 38181790.
  4. Dellinger RW, Holmes HE, Hu-Seliger T, Butt RW, Harrison SA, Mozaffarian D, Chen O, Guarente L. Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double-blind, placebo-controlled clinical trial. Hepatology. 2023 Sep 1;78(3):863-877. doi: 10.1002/hep.32778. Epub 2022 Nov 22. PMID: 36082508.
  5. Tominaga K, Tominaga N, Williams EO, Rufibach L, Schöwel V, Spuler S, Viswanathan M, Guarente LP. 4-Phenylbutyrate restores localization and membrane repair to human dysferlin mutations. iScience. 2021 Dec 20;25(1):103667. doi: 10.1016/j.isci.2021.103667. PMID: 35028538; PMCID: PMC8741482.
  6. Bobrowska A, Donmez G, Weiss A, Guarente L, Bates G. Correction: SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington’s Disease Phenotypes In Vivo. PLoS One. 2021 Mar 25;16(3):e0248926. doi: 10.1371/journal.pone.0248926. Erratum for: PLoS One. 2012;7(4):e34805. doi: 10.1371/journal.pone.0034805. PMID: 33765019; PMCID: PMC7993610.
  7. Simic P, Vela Parada XF, Parikh SM, Dellinger R, Guarente LP, Rhee EP. Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI. BMC Nephrol. 2020 Aug 13;21(1):342. doi: 10.1186/s12882-020-02006-1. PMID: 32791973; PMCID: PMC7427083.
  8. Marinescu AG, Chen J, Holmes HE, Guarente L, Mendes O, Morris M, Dellinger RW. Safety Assessment of High-Purity, Synthetic Nicotinamide Riboside (NR-E) in a 90-Day Repeated Dose Oral Toxicity Study, With a 28-Day Recovery Arm. Int J Toxicol. 2020 Jul/Aug;39(4):307-320. doi: 10.1177/1091581820927406. Erratum in: Int J Toxicol. 2022 Jan-Feb;41(1):47. doi: 10.1177/10915818211063064. PMID: 32715855.
  9. Glorioso CA, Pfenning AR, Lee SS, Bennett DA, Sibille EL, Kellis M, Guarente LP. Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s disease. Life Sci Alliance. 2019 May 27;2(3):e201900303. doi: 10.26508/lsa.201900303. PMID: 31133613; PMCID: PMC6537750.
  10. Igarashi M, Miura M, Williams E, Jaksch F, Kadowaki T, Yamauchi T, Guarente L. NAD+ supplementation rejuvenates aged gut adult stem cells. Aging Cell. 2019 Jun;18(3):e12935. doi: 10.1111/acel.12935. Epub 2019 Mar 27. PMID: 30917412; PMCID: PMC6516145.
  11. Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 2019 Feb 7;176(4):944-945. doi: 10.1016/j.cell.2019.01.026. Erratum for: Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008. PMID: 30735637; PMCID: PMC6429953.
  12. de la Rubia JE, Drehmer E, Platero JL, Benlloch M, Caplliure-Llopis J, Villaron-Casales C, de Bernardo N, AlarcÓn J, Fuente C, Carrera S, Sancho D, GarcÍa-Pardo P, Pascual R, JuÁrez M, Cuerda-Ballester M, Forner A, Sancho-Castillo S, Barrios C, Obrador E, Marchio P, Salvador R, Holmes HE, Dellinger RW, Guarente L, Estrela JM. Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study. Amyotroph Lateral Scler Frontotemporal Degener. 2019 Feb;20(1-2):115-122. doi: 10.1080/21678421.2018.1536152. Epub 2019 Jan 22. PMID: 30668199.
  13. Herskovits AZ, Hunter TA, Maxwell N, Pereira K, Whittaker CA, Valdez G, Guarente LP. SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis. Aging Cell. 2018 Dec;17(6):e12839. doi: 10.1111/acel.12839. Epub 2018 Oct 8. PMID: 30295421; PMCID: PMC6260920.
  14. Dellinger RW, Santos SR, Morris M, Evans M, Alminana D, Guarente L, Marcotulli E. Erratum: Author Correction: Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. NPJ Aging Mech Dis. 2018 Aug 20;4:8. doi: 10.1038/s41514-018-0027-1. Erratum for: NPJ Aging Mech Dis. 2017 Nov 24;3:17. doi: 10.1038/s41514-017-0016-9. PMID: 30155270; PMCID: PMC6102308.
  15. Chen H, Shen F, Sherban A, Nocon A, Li Y, Wang H, Xu MJ, Rui X, Han J, Jiang B, Lee D, Li N, Keyhani-Nejad F, Fan JG, Liu F, Kamat A, Musi N, Guarente L, Pacher P, Gao B, Zang M. DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease. Hepatology. 2018 Aug;68(2):496-514. doi: 10.1002/hep.29849. Epub 2018 May 21. PMID: 29457836; PMCID: PMC6097912.
  16. Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008. Erratum in: Cell. 2019 Feb 7;176(4):944-945. doi: 10.1016/j.cell.2019.01.026. PMID: 29570999; PMCID: PMC5884172.
  17. Hayashi H, Cherpokova D, Martinod K, Witsch T, Wong SL, Gallant M, Cifuni SM, Guarente LP, Wagner DD. Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice. PLoS One. 2017 Dec 13;12(12):e0188341. doi: 10.1371/journal.pone.0188341. PMID: 29236713; PMCID: PMC5728566.
  18. Dellinger RW, Santos SR, Morris M, Evans M, Alminana D, Guarente L, Marcotulli E. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. NPJ Aging Mech Dis. 2017 Nov 24;3:17. doi: 10.1038/s41514-017-0016-9. Erratum in: NPJ Aging Mech Dis. 2018 Aug 20;4:8. doi: 10.1038/s41514-018-0027-1. PMID: 29184669; PMCID: PMC5701244.
  19. Zainabadi K, Liu CJ, Caldwell ALM, Guarente L. SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis. PLoS One. 2017 Sep 22;12(9):e0185236. doi: 10.1371/journal.pone.0185236. PMID: 28937996; PMCID: PMC5609767.
  20. Wellman AS, Metukuri MR, Kazgan N, Xu X, Xu Q, Ren NSX, Czopik A, Shanahan MT, Kang A, Chen W, Azcarate-Peril MA, Gulati AS, Fargo DC, Guarente L, Li X. Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota. Gastroenterology. 2017 Sep;153(3):772-786. doi: 10.1053/j.gastro.2017.05.022. Epub 2017 May 26. PMID: 28552621; PMCID: PMC5581719.
  21. Zainabadi K, Liu CJ, Guarente L. SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2. PLoS One. 2017 May 25;12(5):e0178520. doi: 10.1371/journal.pone.0178520. PMID: 28542607; PMCID: PMC5444833.
  22. Satoh A, Imai SI, Guarente L. The brain, sirtuins, and ageing. Nat Rev Neurosci. 2017 May 18;18(6):362-374. doi: 10.1038/nrn.2017.42. PMID: 28515492.
  23. Cha Y, Han MJ, Cha HJ, Zoldan J, Burkart A, Jung JH, Jang Y, Kim CH, Jeong HC, Kim BG, Langer R, Kahn CR, Guarente L, Kim KS. Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis. Nat Cell Biol. 2017 May;19(5):445-456. doi: 10.1038/ncb3517. Epub 2017 Apr 24. PMID: 28436968; PMCID: PMC5545746.
  24. Ondracek CR, Frappier V, Ringel AE, Wolberger C, Guarente L. Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment. Cell Rep. 2017 Mar 7;18(10):2310-2319. doi: 10.1016/j.celrep.2017.02.031. PMID: 28273448; PMCID: PMC5407064.
  25. Igarashi M, Guarente L. (2017). NAD+ supplementation rejuvenates aged gut adult stem cells via the SIRT1/mTORC1 axis. In review.
  26. Glorioso C, Pfenning AR, Bennett DA, Sibille E, Kellis M, Guarente L (2017). Molecular brain aging and APOEε4 are independent and additive risk for Alzheimer’s disease. In review.
  27. Ondracek CR, Frappier V, Ringel AE, Wolberger C, Guarente L (2017). Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment. Cell Rep. 18, 2310-2319. doi: 10.1016/j.celrep.2017.02.031.
  28. Williams EO, Taylor AK1, Bell EL, Lim R1, Kim DM, Guarente L (2016). Sirtuin 1 Promotes Deacetylation of Oct4 and Maintenance of Naive Pluripotency. Cell Rep. Oct 11;17(3):809-820. doi: 10.1016/j.celrep.2016.09.046.
  29. Guarente L. (2016). Overcoming ATM Deficiency by Activating the NAD+/SIRT1 Axis. Cell Metab, 24, 527-528.
  30. Igarashi M, Guarente L. (2016). The unexpected role of mTORC1 in intestinal stem cells during calorie restriction. Cell Cycle Aug 11:1-2. [Epub ahead of print].
  31. Gage FH, Guarente LP, Wagers AJ. (2016). Aging and Rejuvenation: Insights from Rusty Gage, Leonard Guarente, and Amy Wagers. Trends Mol Med. Aug;22(8):633-4. doi: 10.1016/j.molmed.2016.06.011. Epub 2016 Jul 5.
  32. Guarente, L. (2016). The resurgence of NAD⁺. Science. Jun 17;352(6292):1396-7. doi: 10.1126/science.aag1718.
  33. Igarashi M, Guarente L. (2016). mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction. Cell. 2016 Jul 14;166(2):436-50. doi: 10.1016/j.cell.2016.05.044. Epub 2016 Jun 23.
  34. Cunha-Santos J, Duarte-Neves J, Carmona V, Guarente L, Pereira de Almeida L, Cavadas C. (2016). Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway. Nat Commun. May 11;7:11445. doi: 10.1038/ncomms11445.
  35. Chalkiadaki, A. and Guarente, L. (2015). The multi-faceted functions of sirtuins in cancer. Nature Rev. Cancer 15, 608-624.
  36. Guarente L. (2014). Aging research-where do we stand and where are we going? Cell. 159, 15-9. doi: 10.1016/j.cell.2014.08.041.
  37. Nakagawa T, Guarente L. (2014). SnapShot: sirtuins, NAD, and aging. Cell Metab. 20, 192-192.e1. doi: 10.1016/j.cmet.2014.06.001.
  38. Bell EL, Nagamori I, Williams EO, Del Rosario AM, Bryson BD, Watson N, White FM, Sassone-Corsi P, Guarente L. (2014). SirT1 is required in the male germ cell for differentiation and fecundity in mice. Development 141, 3495-504. doi: 10.1242/dev.110627. Epub 2014 Aug 19.
  39. Imai, S., and Guarente, L. (2014). NAD+ and sirtuins in aging and disease. Trends Cell Biol. 24, 464-71. doi: 10.1016/j.tcb.2014.04.002. Epub 2014 Apr 29
  40. Chalkiadaki, A., Igarashi, M., Nasamu A., Knezevic, J., and Guarente, L. (2014). Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch fibers and Ameliorates Pathophysiology in the Mouse Model of Duchenne Muscular Dystrophy. PLoS Genet. 10 e1004490. doi: 10.1371/journal.pgen.1004490. eCollection 2014 Jul.
  41. Herskovits, A. and Guarente, L. (2014). SIRT1 in neurodevelopment and brain senescence. Neuron 81, 471-483.
  42. Guarente, L. (2014). Between bedside and bench. Sirtuins and the Warburg effect. Nature Med. 20, 24-25.
  43. Chang, H-C. and Guarente, L. (2013). SIRT1 and other sirtuins in metabolism. Trends Endocrin. And Metab. published online Dec. 31.
  44. Fendt SM, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR, Schwab M, Bellinger G, Csibi A, Patnaik A, Blouin MJ, Cantley LC, Guarente L, Blenis J, Pollak MN, Olumi AF, Vander Heiden MG, Stephanopoulos G. (2013). Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Res. 2013 Jul 15;73(14):4429-38. doi: 10.1158/0008-5472.CAN-13-0080. Epub 2013 May 17.
  45. Herskovits AZ, Guarente L. (2013). Sirtuin deacetylases in neurodegenerative diseases of aging. Cell Res. Jun;23(6):746-58. doi: 10.1038/cr.2013.70. Epub 2013 May 21.
  46. Li Y., Wong, K, Giles, A, Jiang, J, Lee, JW, Adams, AC, Kharitonenkov, A, Yang, Q, Gao,B, Guarente, L, Zang, M. (2013). Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. Gastroenterology in press.
  47. Sinclair DA, Guarente L. (2013). Small-Molecule Allosteric Activators of Sirtuins. Annu Rev Pharmacol Toxicol. 2013 Oct 16. [Epub ahead of print].
  48. Hasegawa K, Wakino S, Simic P, Sakamaki Y, Minakuchi H, Fujimura K, Hosoya K, Komatsu M, Kaneko Y, Kanda T, Kubota E, Tokuyama H, Hayashi K, Guarente L, Itoh H. (2013). Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes. Nat Med. Oct 20. doi: 10.1038/nm.3363. [Epub ahead of print].
  49. Guarente L. (2013). Calorie restriction and sirtuins revisited. Genes Dev. 27 :2072-85. doi: 10.1101/gad.227439.113.
  50. Guarente L. (2013). Introduction: sirtuins in aging and diseases. Methods Mol Biol. 1077:3-10. doi: 10.1007/978-1-62703-637-5_1.
  51. Yao H, Hwang JW, Sundar IK, Friedman AE, McBurney MW, Guarente LP, Gu W, Kinnula VL, Rahman I. (2013). SIRT1 redresses tissue inhibitor of matrix metalloproteinase-1/matrix metalloproteinase-9 imbalance in the development of mouse emphysema and human COPD. Am J Physiol Lung Cell Mol Physiol. 2013 Sep 13. [Epub ahead of print].
  52. Guarente L. (2013). Sirtuins and ageing–new findings. EMBO Rep.14(9):750. doi: 10.1038/embor.2013.121. Epub 2013 Aug 9.
  53. Fendt SM, Bell EL, Keibler MA, Olenchock BA, Mayers JR, Wasylenko TM, Vokes NI, Guarente L, Vander Heiden MG, Stephanopoulos G. (2013). Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells. Nat Commun. 4:2236. doi: 10.1038/ncomms3236.
  54. Mouchiroud, L., Houtkooper, R. Moullan, N., Katsyuba, E., Ryu, D., Canto, C., Mottis, A., Jo, Y., Viswanathan, M., Schoonjans, K., Guarente, L., and Auwerx, J. (2013). The NAD+/Sirtuin pathway modulates longevity through activation of the mitochondrial UPR and FOXO signaling. Cell 154, 430-441.
  55. Simic, P., Williams, EO, Bell, E., Gong, JJ, Bonkowski, M., and Guarente, L. (2013). SIRT1 suppresses the epithelial to mesenchymal transition in cancer metastasis and organ fibrosis. Cell Reports 3;1175-86 April 10 Epub.
  56. Simic, P., Zainabadi, K., , Bell, E., Sykes, D., , Saez, B., Lotinun, B.,, Baron, R.,, Scadden, D., Schipani, E.,, and Guarente, L.   SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin.  (2013).   EMBO Mol. Med. In press.
  57. Libert, S., Bonkowski, M., Pointer, K., Pletcher, S. D., and Guarente, L. (2012). Deviation of innate circadian period from 24 h reduces longevity in mice.  Aging Cell,  published online July 12, 2012.
  58. Libert, S. and Guarente, L.  (2012). Metabolic and neuropsychiatric effects of calorie restriction and sirtuins.  Ann Rev. Physiol.  In press.
  59. Chalkiadaki, A. and Guarente, L.  (2012). High fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction.  Cell Metabolism, published online Aug. 7, 2012.
  60. Guarente, L.  (2012).  Sirtuins and calorie restriction.  Nature Rev. Molecular Cell Biology, 13, 207.  published online: 29 February 2012; doi:10.1038/nrm3308
  61. Donmez, G., Arun, A., Chung, C., McLean, P, Lindquist, S., and Guarente, L.  (2012).
    SIRT1 protects against α-synuclein aggregation by activating molecular chaperones.  Journal of Neuroscience 32, 124-132.
  62. Chalkiadaki, A. and Guarente, L.  (2011).  Sirtuins mediate mammalian metabolic responses to nutrient availability. Nature Rev. Endocrinology, published online:17January2012 |doi:10.1038/nrendo.2011.225.
  63. Chalkiadaki, A. and Guarente, L.  (2011).  Metabolic signals regulate SIRT1 expression.  EMBO Reports Sept. 23, 2011.
  64. Guarente, L.  (2011).  Sirtuins, Aging, and Metabolism.  Cold Spring Harbor Symposium on Quantitative Biology, doi:10.1101/sqb.2011.76.010629.
  65. Libert, S., Pointer, K., Bell, E., Das, A., Asara, J., Kapur, K, Bergmann, S., Preisig M., Otowa, T., Kendler, K., Chen, X., Hettema, J., van den Oord, E., Rubio, J., and Guarente, L. (2011).  SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive.  Cell 147, 1459-1472.
  66. Metallo C., Gameiro, P., Bell, E., Hiller, K., Johnson, Z., Guarente, L., Kelleher, K., Vander Heiden, M., Iliopoulos, O., and Stephanopoulos, G.  (2011). Reductive metabolism by IDH1 mediates lipogenesis of human cells under hypoxia.  Nature, online Nov. 20 doi:10.1038/nature10602.
  67. Viswanathan, M., and Guarente, L., (2011).  Regulation of C. elegans life span by sir-2.1 transgenes.  Nature, 477 doi:10.1038/nature10440.
  68. Nadtochiy, S., Yao, H., McBurney, M., Gu , W., Guarente. L., Rahman, I., and Brookes, P. (2011).  SIRT1 mediated acute cardioprotection. American J Physiol. Heart and Circ.
    Physiol.,doi:10.1152/00587.
  69. Yao, H, Chung, S, Hwang, J., Rajendrasozhan, S., Sundar, I., Dean, D. McBurney, M., Guarente,
    L.    , Gu,W., Mikko, R., Kinnula, V. L., and Rahman, I.  (2011).  Sirtuin 1 protects against pulmonary emphysema via FOXO3 mediated reduction of premature senescence. J Clin Invest doi:10.1172/JCI60132.
  70. Hyunkyung, J., Cohen, D, Cui, L., Supinski, A., Savas3, J., Mazzulli, J., Yates, J., Bordone, L., Guarente, L., and Krainc, D.  (2011).  Sirt1 mediates neuroprotection from mutant huntingtin by activation of TORC1and CREB transcriptional pathway.  Nature Medicine, online Dec. 18. doi:10.1038/nm.2559.
  71. Hasegawa, K.,Wakino, S., Simic, P., Sakamak3, Y., Minakuchi, H., Fujimura, K., Hosoya, K., Komatsu, M., Kaneko, Y., Kanda, T., Kubota, E.,  Tokuyama, H., Hayashi, K., Guarente, L., and Itoh, H.,  (2011). The Protective Role of Renal Tubular Sirt1 in the Initiation of Diabetic Nephropathy 1 through the Epigenetic Regulation of Glomerular Expression of Tight-junction Protein Claudin-1. Submitted.
  72.  Guarente, L. (2011).  The logic that links protein acetylation and metabolism.  Cell Metab. 14, 151-153.
  73. Guarente L. (2011). Connecting the dots: linking sirtuins and AMPK in metabolism and aging. Dev Cell. Apr 19; 20(4):e1.
  74. Bell, E. and Guarente, L.  (2011).  The SIRT3 Divining rod points to oxidative damage.  Mol. Cell, 42, 511-520.
  75. Guarente, L.  (2011).  Sirtuins, Aging, and Medicine.   New England Journal of Medicine, 364, 2235-2244.
  76. Li, Y., Xu, S, Giles, A., Nakamura, K., Lee, J., Hou, X, Donmez, G., Li, J., Luo, Z, Walsh, K, Guarente, L., and Zang, M.  (2011).  Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver.  FASEB J.  Feb. 14 (Epub ahead of print)
  77. Bell, E. L., Emerling, B., Ricoult, S. and Guarente L.  (2011).  Sirt3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS production.  Oncogene, Feb 28. [Epub ahead of print].
  78. Nakagawa, T., and Guarente, L.  Sirtuins at a glance.  (2011).  J. Cell Science Mar 15;124 (Pt 6):833-8.
  79. Berdichevsky, A., Nedelcu, S., Boulias, K., Nicholas Bishop, N., Guarente, L., and Horvitz, H.
    R.  (2010).  3-Ketoacyl thiolase delays aging of C. elegans and is required for longevity mediated by sir-2.1. Proc. Nat. Acad. Sci. 44, 18927-18932.
  80. Donmez, G., and Guarente, L. (2010).  Aging and disease: connections to sirtuins.  Aging Cell 2, 285-290.
  81. Asai,S., Zaima, N., Ikegami, K., Kahyo, T., Yao,I., Hatanaka, T., Iemura, S., Sugiyama, R., Yokozeki, T., Eishi, Y., Koike, M., Ikeda, K., Chiba, T., Yamaza, H., Shimokawa, I., Song, S-Y.,
    Matsuno, A., Mizutani, A., Sawabe, M., Chao, M., Tanaka, M., Kanaho, M., Natsume, T., Sugimura, H., Date, Y.,  McBurney, M., Guarente, L., and Setou, M.  SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kc Activity through Deacetylation of Specific Lysine Residues in Mammals (2010).  PLOS ONE 5, e11755.  Jul. 23, 2010.
  82. Bauer et al., Dietary Restriction: standing up for sirtuins.  (2010). Science  329, 1012-1013.
  83. Donmez, G., Wang, D., Cohen, D., and Guarente, L.  (2010).  SIRT1 suppresses beta-amyloid production by activating the alpha-secretase ADAM10.  Cell  142, 320-332.
  84. Berdichevsky, A., Guarente, L., Avirup Bose  (2010). Acute oxidative stress can reverse insulin resistance by inactivation of cytoplasmic JNK.  J. Biol. Chem.  Published online April 29.
  85. Imai, S., Guarente, L. (2010).  Ten years of NAD-dependent SIR2 deacetylases: implications for metabolic diseases.  TIPS,  online April 4. 
  86. Guarente, L.  (2010).  Forever Young.  Cell  140,  176-178.  
  87. Cohen, D, Supinski, A., Bonkowski, M. Donmez, G.,and Guarente, L  (2009).  Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction.  Genes Dev, 23, 2812-2817. 
  88. Guarente, L.  (2009).  Hypoxic hookup.  Science, 324, 12-13.
  89. Nakagawa, T., Haigis, M., Lomb, D., and Guarente, L.  (2009). SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.  Cell, 137, 560-570.
  90. Liu, Y.*, Dentin, R*., Chen, D.*, Ravnskjaer, K., Cole, P., Olefsky, J., Yates, J., Guarente, L. and Montminy, M.  (2008)  SIRT1-modulated gluconeogenesis via deacetylation of TORC2. Nature, 456, 269-273.
  91. Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Kiravama, J., Chen, D., Brunet, A., Guarente., L, and Sassone-Corsi, P. (2008) The NAD-dependent Deacetylase SIRT1 Operates with CLOCK in Regulating Chromatin Remodeling and Circadian Control. (Cell in press)
  92. Firestein, R., Blander, G., Michan, S., Oberdoerffer, P., Ogino, S., Campbell, J., Bhimavarapu, A., Luikenhuis, S., deCabo, R., Fuchs, C., Hahn, W., Guarente, L., and Sinclair, D. (2008) The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS ONE Apr. 16, 3, e2020.
  93. Chen, D.*, Steele, A.*, Hutter, G., Bruno, J., Govindarajan, A., Easlon, E., Lin, SJ., Aguzzi, A., Lindquist, S. and Guarente, L. Calorie restriction and SIRT1 depletion delay the onset of prion disease. (invited revision in Aging Cell ).
  94. Chen, D., Bruno, J., Easlon, E., Lin, SJ., Alt, F. and Guarente, L. Tissue-specific regulation of SIRT1 by calorie restriction. Genes & Dev. In press.
  95. Blander, G., et al., (2008). SIRT1 promotes differentiation of normal kerotinocytes. Journal of Investigative Dermatology, in press.
  96. Libert, S., Cohen, D., and Guarente, L. (2008). Neurogenesis directed by SIRT1. Nature Cell Biol. 10, 373-374.
  97. Guarente, L. (2008). Mitochondria — a nexus for aging, calorie restriction and sirtuins?. Cell 132, 171-175.
  98. Guarente, L. (2007). Sirtuins in aging and disease. CSH Symp. Quant. Biol. 72, 483-488.
  99. Westphal, C., Dipp, M., and Guarente, L. (2007). A therapeutic role for sirtuins in diseases of aging? TIBs 32, 555-560.
  100. Lombard et al. (2007). Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol. Cell Biol 27, 8807-8814.
  101. Werner, H. et al., (2007). Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neuroscience 27, 7717-7730.
  102. Bishop, N. and Guarente, L. (2007). Genetic links between diet and lifespan. Nature Reviews 8, 835-844.
  103. Chen, D. and Guarente, L. (2007) SIR2: a portential target for calorie restriction mimetics. Trends Mol Med 13, 64-71.
  104. Bordone, L., Robinson, A., van Veen, E., Motta, M. C., Smith, C., Lintz, H., Marmor, S., Luo, J., deCabo, R., Gu, W., and Guarente, L. (2007). SIRT1 transgenic mice display calorie restriction -like phenotypes. Aging Cell, 6, 759-767.
  105. Bordone, L., Robinson, A., van Veen, E., Motta, M. C., Smith, C., Lintz, H., Marmor, S., Luo, J., deCabo, R., Gu, W., and Guarente, L. (2007). SIRT1 transgenic mice display calorie restriction -like phenotypes. Aging Cell, 6, 759-767.
  106. Li, X., Zhang, S., Blander, G., Tse, J. G., Krieger, M., and Guarente, L. (2007). SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell 28, 91-106.
  107. Bishop, N., and Guarente, L., (2007). Skn-1 acts in two neurons to mediate calorie restriction-induced longevity in C. elegans. Nature 447, 545-549.
  108. Kume, S., Haneda, M., Kanasaki, K., Sugimoto, T., Araki, S., Isshiki, K., Isono, M., Uzu, T., Guarente, L., Kashiwagi, A., and Koya, D. (2007). SIRT1 inhibits TGFb-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. J. Biol. Chem. 282, 151-158.
  109. Guarente, L., (2006). Sirtuins as potential targets for metabolic syndrome. Nature, 444, 868-874.
  110. Berdichevsky, A., and Guarente, L. (2006). A stress response pathway involving sirtuuins, 14-3-3 proteins, and forkhead. Cell cycle. E-pub.
  111. Haigis, M., and Guarente, L. (2006). Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev. 20, 2913-2921.
  112. Sinclair, D., and Guarente, L. (2006). Unlocking the secrets of longevity genes. Scientific American. March 2006, pp. 48-57.
  113. Ford, E., Voit, R., Liszt, G., Grummt, I., and Guarente, L., (2006). Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev. 20, 1075-1081.
  114. Ford, E., Voit, R., Liszt, G., Grummt, I., and Guarente, L., (2006). Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev. 20, 1075-1081.
  115. Haigis, M., Mostoslavsky, R., Haigis, K., Christodolou, D., Murphy, A., Valenzuala, D., Yancopoulos, G., Karow, M., Blander, G., Weindruch, R., Alt, F., and Guarente, L. (2006). SIRT4 regulates glutamate dehydrogenase and insulin secretion in pancreatic beta cells. Cell 126, 941-954.
  116. Berdichevsky, A., Viswanathan, M., Horvitz, R., and Guarente, L. (2006). C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend lifespan. Cell, 16, 1165-1178.
  117. Mostoslavsky, R., Chua, K., Lombard, D., Pang, W., Fischer, M., Gellon, L., Liu, P., Mostoslavsky, G. Franco, S., Murphy, M., Mills, K., patel, P., Hsu, J., Hong, A., Ford, E., Cheng, H., Kennedy, K., Nunez, N., Bronson, R., Frendewey, D., Auerbach, W., Valenzuela, D., Karow, M., Hursting, S., Barrett, J., Guarente, L., Mulligan, R., Demple, B., Yancopoulos, G., andf Alt, F. (2006). Genome instability and aging-like phenotype in the absence of mammalian Sirt6. Cell 124, 315-330.
  118. Liszt, G., Ford, E., Kurtev, M., and Guarente, L. (2005). Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J. Biol. Chem. 280, 21313-21320.
  119. Chen, D., Steele, A., Lindquist, S., and Guarente, L. (2005). Increase in activity during calorie restriction requires Sirt1. Science, 310, 1641.
  120. Bordone, L., Motta, M., Picard, F., Robinson, A., Jhala, U., Apfeld, J., McDonough, T., Lemieux, M., McBurney, M., Ealson, E., Lin, S., and Guarente, L. (2005). Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biology 4, 210-220 (published online Dec 2005).
  121. Guarente, L. (2005). NO link between calorie restriction and mitochondria. Nature Chem. Biol. 1, 366-367.
  122. Guarente, L. (2005). Calorie restriction and SIR2 genes—Towards a mechanism. Mechanisms of aging and devel. 126, 923-928.
  123. Bordone, L. and Guarente, L. (2005). SIRT1 and Metabolism: understanding longevity. Nature. Rev. Mol. Cell Biol. 6, 298-305.
  124. Guarente, L. and Picard, F. (2005). Calorie Restriction—the SIR2 connection. Cell 120, 473-482.
  125. Blander G, Olejnik J, Krzymanska-Olejnik E, McDonagh T, Haigis M, Yaffe M, and Guarente L. (2005). SIRT1 Shows No Substrate Specificity in Vitro. J. Biol. Chem. 280, 9780-5.
  126. Chang, S., Mulani, A., Cabera, N., Naylor, M., Laud, P., Lonbard, D., Pathak, S., Guarente, L., and DePinho, R. (2004). Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat. Gen., 36, 877-882.
  127. Du, X., Shen, J., Kugan, N., Furth, E., Lonbard, D., Cheung, C., Pak, S., Luo, G., Pignolo, R., DePinho, R., Guarente, L., and Johnson, B. (2004). Telomere shortening exposes functions for the mouse Werner and Bloon syndrome genes. Mol. Cell Bio., 24, 8437-8446.
  128. Blander, G. and Guarente, L. (2004). The SIR2 family of protein deacetylases. Ann Rev. Biochem. 73, 417-436.
  129. Kaeberlein, M., Andalis, A., Liszt, G., Fink, G., and Guarente, L. (2004). Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism. Genetics, 166, 1661-1672.
  130. Motta, M. C., Divecha, N., Lemieux, M., Kamel, C., Chen, D., Gu, W., Bultsma, Y., McBurney, M., and Guarente, L. (2004). Mammalian SIRT1 represses forkhead transcription factors. Cell 116, 551-563.
  131. Picard, F., Kurtev, M., Chung, N., Topark-Ngarmm, A., Senawong, T, Machado de Oliveira, R., Leid, M, McBurney, M. and Guarente, L. (2004). SIRT1 promotes fat mobilization in white adipocytes by repressing PPAR-g. Nature, 429, 771-776. published online June 2.
  132. Lin, S. J., Ford, E., Haigis, M., Liszt, G., and Guarente, L. (2004). Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev. 18, 12-16.
  133. Blander G, de Oliveira RM, Conboy CM, Haigis M, Guarente L. (2003). Superoxide dismutase 1 knock-down induces senescence in human fibroblasts. J. Biol. Chem. 278, 38966-9.
  134. Guarente, L. (2003). Ageless quest. Cold Spring Harbor Press, New York.
  135. Hekimi, S. and Guarente, L. (2003) Genetics and the specificity of the aging process. Science, 299, 1351-1354.
  136. Lin, S. J. and Guarente, L. (2003). Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity, and disease. Current Opinion in Cell Biology 15, 241-246.
  137. Kubova, J., and Guarente, L. (2003). How does calorie restrriction work? Genes and Dev. 17, 313- 321.
  138. Kubova, J., and Guarente, L. (2003). How does calorie restrriction work? Genes and Dev. 17, 313- 321.
  139. Kaeberlein, M., Andalis, A., Fink, G., and Guarente, L. (2002). High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. Mol. Cell Biol. 22, 8056-8066.
  140. Lin, S. J. Kaeberlein, M., Andalis, A., Sturtz, L. A., Defossez, P., Culotta, V. C., Fink, G. R. and Guarente, L. (2002). Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature, 418, 344-348.
  141. Armstrong, C., and Guarente, L. (2002). Mutations in the S. cerevisiae SIR2 gene can have differential effects on silencing in vivo and histone deacetylation in vitro. Mol. Biol. Cell. 13, 1427-1438.
  142. 156. Kaeberlein, M., and Guarente, L. (2002). Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics, 160, 83-95.
  143. Tissenbaum, H., and Guarente, L. (2002) Model organisms as a guide to mammalian aging. Dev. Cell, 2, 9-19.
  144. Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S.-I., Frye, R. A., Pandita, T. K., Guarente, L., and Weinberg, R. A. (2001). hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase. Cell 107, 149-159.
  145. Luo, J., Nikolaev, A. Y., Imai, S., Chen, D., Shiloh, A., Guarente, L., and Gu, W. (2001). Negative control of p53 by Sir2a promotes cell survival under stress. Cell 107, 137-148.
  146. Marciniak, R., and Guarente, L. (2001) Testing telomerase. Nature, 413, 370-373.
  147. Park, P. U., McVey, M., and Guarente, L. (2001). Separation of mother and daughter cells. Meth. Enz. In press.
  148. Hu, P., Beresten, S., van Brabant, A., Ye, T.-Z., Pandolphi, P., Johnson, F. B., Guarente, L., and Ellis, N. (2001). Evidence for BLM and topoisomerase IIIa interaction in genomic stability. Hum. Mol. Gen. 10, 1287-1298.
  149. Guarente, L. (2001). SIR2 and aging—the exception that proves the rule. Trends Gen. 17, 393-393.
  150. McVey, M., Kaeberlein, M., Tissenbaum, H., and Guarente, L. (2001). The short life span of S. cerevisiae sgs1 and srs1 mutants is a composite of normal aging processes and a Rad9-dependent cell cycle arrest. Genetics, 157, 1531-1542.
  151. Tissenbaum, H., and Guarente, L., (2001). Increased dosage of a C. elegans sir-2 gene extends life span in C. elegans. Nature, 410, 227-230.
  152. Johnson, F. B., Marciniak, R., McVey, M., Stewert, S., Hahn, W., and Guarente, L. (2001). The S. cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase. EMBO J. 20, 905-913.
  153. Guarente, L. and Kenyon, C. (2000). Genetic pathways that regulate aging in model organisms. Nature, 408, 255-262.
  154. Lin, S. J., Defossez, P.-A., and Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in S. cerevisiae. Science, 289, 2126-2128.
  155. Imai, S., Johnson, F. B., Marciniak, R., McVey, M., Park, P., and Guarente, L. (2000). Sir2: An NAD- dependent histone deacetylase that connects chromatin silencing, metabolism, and aging. Cold Spring Harbor Symp. Quant. Biol. in press
  156. Yankiwski, v., Marciniak, R. A., Guarente, L., and Neff, N. (2000) Nuclear structure in normal and Bloom syndrome cells. Proc. Nat. Acad. Sci. 97, 5214-5219.
  157. Guarente, L. (2000). Sir2 links chromatin silencing, metabolism, and aging. Genes Dev. 14, 1021-1026.
  158. Lombard, D. B., and Guarente, L. (2000). Nijmegen breakage syndrome disease protein and Mre11 at PML nuclear bodies and meiotic telomeres. Cancer Res. 60, 2331-2334.
  159. Marciniak, R. A., Johnson, F. B., and Guarente, L. (2000). Dyskeratosis Congenita, telomeres, and aging. Trends Gen. 16, 193-195.
  160. Johnson, F. B., Lombard, D., Neff, N., Mastrangelo, A., Dewolf, W., Ellis, N., Marciniak, R., Yin, Y., Jaenisch, R., and Guarente, L. (2000). Association of the Bloom syndrome protein with topoisomerase IIIa in somatic and meiotic cells. Cancer Res. 60, 1162-1167.
  161. Tissenbaum, H., Hawson, J., Perregaux, M., Hotez, P., Guarente, L., and Ruvkun, G. (2000). A common Muscarinic pathway in the distantly related nematode species C. elegans and Ancylostoma canium. Proc. Nat. Acad. Sci. 97, 460-465.
  162. Lombard, D. B., Beard, C., Dausman, J., Bronson, R., Lipman, R., Buhlman, J., Curry, R., Sharpe, A., Johnson, F. B., Marciniak,, R., Jaenisch, R., and Guarente, L. (2000). Mutations in the WRN gene in mice accelerate mortality in a p53 null background. Mol. Cell. Biol. 20, 3286-3291.
  163. Imai, S., Armstrong, C., and Guarente, L. (2000). Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature, 403, 795-800.
  164. Guarente, L. (1999). Extending mammalian life span. Nature 402, 243-245.
  165. Guarente, L. (1999). Diverse and dynamic new functions of the Sir silencing complex. Nat. Genet. 23, 281-286.
  166. Kaeberlein, M., McVey, M., and Guarente, L. (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in S. cerevisiae by two different mechanisms. Genes Dev. 13, 2570-2581.
  167. Ashrafi, K., Sinclair, D., Gordon, J., and Guarente, L. (1999). Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. 96, 9100-9105.
  168. Ashrafi, K., Sinclair, D., Gordon, J., and Guarente, L. (1999). Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. 96, 9100-9105.
  169. King, D.A., Zhang, L., Guarente, L., and Marmorstein, R. (1999). Structure of a HAP1-18-DNA Implicates Direct Allosteric Effect of Protein-DNA Interactions on Transcriptional Activation. Nature Structural Biol., 6, 22-27.
  170. King, D.A., Zhang, L., Guarente, L., and Marmorstein, R. (1999). Structure of a HAP1-DNA Complex Reveals Dramatically Asymmetric DNA binding by a Homodimeric Protein. Nature Structural Biol., 6, 64-71.
  171. Mills, K.D., Sinclair, D.A., and Guarente, L. (1999). MEC1 -dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell, 97, 609-620.
  172. Defossez, P.A., Prusty, R., Kaeberlein, M., Lin, S., Ferrigno, P., Silver, P., Keil, R., and Guarente, L. (1999). Elimination of Yeast Replication Block Protein Fob1p Extends the Life Span of Mother Cells. Molecular Cell, 3, 447-455.
  173. Park, P.U., Defossez, P.A., and Guarente, L. (1999). Effects of Mutations in DNA Repair Genes on the Formation of rDNA Circles and Life-span in S. cerevisiae. Mol. Cell. Biol., 19: 3848-3856.
  174. Johnson, F. B., Sinclair, D., and Guarente, L. (1999). Molecular biology of aging. Cell 96, 291-302.
  175. Defossez, P.A., Park, P. U., and Guarente, L. (1998). Vicious circles: a mechanism for yeast aging. Current Opinion in Microbiology, 1, 707-711.
  176. Guarente, L., Ruvkun, G., and Amasino, R. (1998). Aging, life span, and senescence. Proc. Natl. Acad. Sci. 95, 11034-11036.
  177. Johnson, F. B., Marciniak, R. M., and Guarente, L. (1998). Telomeres, the nucleolus, and aging. Current Opinion in Cell Biology 10, 332-338.
  178. Marciniak, R.A., Lombard, D., Johnson, F. Bradley, and Guarente, L. (1998). Nucleolar localization of the Werner syndrome protein in human cells. Proc. Natl. Acad. Sci. 95, 6887-6992.
  179. Sinclair, D., Mills, K., and Guarente, L. (1998). Molecular mechanisms of yeast aging. TIBS 23, 131-134.
  180. McNabb, D., Tseng, K., and Guarente, L. (1997). The Saccharomyces cerevisiae Hap5p homolog from fission yeast reveals two conserved domains that are essential for assembly of heterotetrameric CCAAT-binding factor. Mol. Cell. Biol. 17, 7008-7018.
  181. Sinclair, D., and Guarente, L. (1997). Extrachromosomal rDNA circles – a cause of yeast aging. Cell 91, 1033-1042.
  182. Guarente, L. (1997). Link between aging and the nucleolus. Genes and Devel. 11, 2449-2555.
  183. Sinclair, D., Mills, K., and Guarente, L. (1997). Accelerated Aging and Nucleolar Fragmentation in Yeast sgs1 Mutants. Science, 277, 1313-1316.
  184. Austriaco, N., and Guarente, L. (1997). Inverse correlation between telomere length and lifer span in Saccharomyces cerevisiae. Proc. Nat. Acad. Sci. 94, 9768-9772.
  185. McNabb, D., Pak, S., and Guarente, L. (1997). Construction of a hisG-ura4+-hisG cassette for sequential gene disruptions in the yeast Schizosaccharomyces pombe. BioTechiques 22, 1134-1139.
  186. Horiuchi, J., Silverman, N., Pina, B, Marcus, G., and Guarente, L. (1997). ADA1, a novel component of the ADA/GCN5 complex has broader effects of GCN5, ADA2, ADA3. Mol. Cell. Biol. 17, 3220-3228.
  187. Silverman, N., and Guarente, L. (1997). Of acetylation, activation, and toxicity, the role of the ADA/GCN5 complex in trancription. Nucleic Acids and Molecular Biology 11, 305-319.
  188. Guarente, L. (1997). What makes us tick? Science 275, 943-944.
  189. Kennedy, B., Gotta, M., Sinclair, D., Mills, K., McNabb, D., Marthy, M., Pak, S., Laroche, T., Gasser, S., and Guarente, L. (1997). Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell 89, 381-392.
  190. Smeal, T., and Guarente, L. (1997). Mechanisms of cellular senescence. Current Opinion in Genetics and Development 7, 281-287.
  191. McNabb, D., and Guarente, L. (1996). Genetic and biochemical probes for protein-protein interaction. Current Opinion in Biotechnology 7, 554-559.
  192. Guarente, L. (1996). Do changes in chromosomes cause aging? Cell, 86, 9-12.
  193. Lombard, D., and Guarente, L. (1996). Cloning the gene for Werner’s syndrome, a disease with many symptoms of premature aging. Trends in Genetics 12, 283-286.
  194. Kennedy, B., and Guarente, L. (1996). Genetic Analysis of Aging in Saccharomyces cerevisiae. Trends in Genetics 12, 355-359.
  195. Marcus, G.A., Silverman, N., and Guarente, L. (1996). Cloning and Characterization of ADA5/SPT20: A Gene with Properties of Two Transcriptional Superfamilies. Mol. Cell Biol. 6, 3197-3205.
  196. Zhang, L., and Guarente, L. (1996). The Determinant of Asymetric Binding by HAP1 — The C6 Zinc Cluster. EMBO J., 15, 4676-4681.
  197. Smeal, T., Claus, J., Kennedy, B.K., Cole, F., and Guarente, L. (1996). Loss of Transcriptional Silencing in Old Mother Cells of Saccharymoces Cerevisiae. Cell, 84, 633-642.
  198. Knaus, R., Pollock, R., and Guarente, L. (1996). Yeast SUB1: A Suppressor of a TFIIB mutation with homology to the human coactivator PC4. EMBO J. 8, 1933-1940.
  199. Guarente, L. (1995). Transcriptional coactivators in yeast and beyond. TIBS 12, 517-521.
  200. Haldi, M., and Guarente, L. (1995). Heme is required for both the DNA-binding and transcriptional activation functions of the yeast activator HAP1. Mol. Gen. Genet., 248, 229-235.
  201. Berger, S.L., Turcotte, B., and Guarente, L. (1995). The acidic transcriptional activation domains of herpes virus VP16 and yeast HAP4 have different cofactor requirements. Genes, 158, 163-173.
  202. McNabb, D., Xing, Y., and Guarente, L. (1995). Cloning of yeast HAP5: a novel subunit of a heterotrimeric complex required for CCAAT-binding. Genes & Devel., 9, 47-58.
  203. Kennedy, B., Austriaco, N., Zhang, J., and Guarente, L. (1995). Mutation in the silencing gene SIR4 can delay aging in Saccharomyces cerevisiae. Cell, 80, 485-496.
  204. Horiuchi, J., Silverman, N., Marcus, G.A., and Guarente, L. (1995). ADA3, a putative transcriptional adaptor, consists of two separable domains and interacts with ADA2 and GCN5 in a trimeric complex. Mol. Cell. Biol., 15, 1203-1209.
  205. Zhang, L., and Guarente, L. (1995). A short protein motif binds heme and modulates the activity of a transcriptional activator HAP1. EMBO J., 14, 313-320.
  206. Kennedy, B.K., Austriaco, N.R., Jr., and Guarente, L. (1994). Daughter cells of S. cerevisiae from old mothers display a reduced life span. J. Cell Biol., 137 1985-1993.
  207. Silverman, N., Agapite, J., and Guarente, L. (1994). Yeast ADA2 binds to the VP16 activation domain and activates transcription. Proc. Natl. Acad. Sci USA , 91, 11665-11668.
  208. Zhang, L., and Guarente, L. (1994). The yeast activator HAP1 – a GAL4 family member – binds DNA in a directly repeated orientation. Genes and Devel., 8: 2110-2119.
  209. Xing, Y., Zhang, S., Olesen, J.T., Rich, A., and Guarente, L. (1994). Subunit interaction in the CCAAT-binding heteromeric complex is mediated by a very short a-helix in HAP2. Proc. Natl. Acad. Sci. USA 91: 3009-3013.
  210. Zhang, L., and Guarente, L. (1994). HAP1 is nuclear but is bound to a cellular factor in the absence of heme. J. Biol. Chem. 269: 14643-14647.
  211. Zhang, L., and Guarente, L. (1994). Evidence that TUP1/SSN6 has a positive role on the activity of the yeast activator HAP1. Genetics 136: 813-817.
  212. Xing, Y., Fikes, J.D., and Guarente, L. (1993). Mutations in yeast HAP2-HAP3 define a hybrid CCAAT box-binding domain. EMBO J. 12: 4647-4655.
  213. Pina, B., Berger, S., Marcus, G.A., Silverman, N., Agapite, J., and Guarente, L. (1993). ADA3: A gene identified by resistance to GAL4-VP16 with properties similar to and different from ADA2. Mol. Cell. Biol. 13: 5981-5989.
  214. Guarente, L. (1993). Synthetic enhancement in gene interaction: A genetic tool come of age. Trends in Genetics 9: 362-366.
  215. Guarente, L. (1993). Commentary: Strategies for the identification of interacting proteins. Proc. Natl. Acad. Sci. USA 90: 1639-1641.
  216. Zhang, L., Bermingham-McDonogh, O., Turcotte, B., and Guarente, L. (1993). Antibody-promoted dimerization bypasses the regulation of DNA-binding by the heme domain of yeast transcriptional activator HAP1. Proc. Natl. Acad. Sci. USA 90: 2851-2855.
  217. Turcotte, B., and Guarente, L. (1992). HAP1 positive control mutants specific for one of two binding sites. Genes and Devel. 6: 2001-2009.
  218. Berger, S.L., Pina, B., Silverman, N., Marcus, G.A., Agapite, J., Regier, J.L., Triezenberg, S.J., and Guarente, L. (1992). Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains. Cell 70: 251-265.
  219. Eide, D., and Guarente, L. (1992). Increased dosage of a transcriptional activator gene enhances iron-limited growth of Saccharomyces cerevisiae. J. Gen. Microbiol. 138: 347-354.
  220. Guarente, L., and Bermingham-McDonogh, O. (1992). Conservation and evolution of transcriptional mechanisms in eukaryotes. Trends in Genetics 8: 27-32.
  221. Guarente, L. Mechanism and regulation of transcriptional activation in eukaryotes: Conserved features from yeasts to humans (1992). In: Transcriptional Regulation (McKnight and Yamamoto, eds.). Cold Spring Harbor Press, New York.
  222. Guarente, L. Messenger RNA transcription and its control in Saccharomyces cerevisiae (1992). In: The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression (Jones, Pringle and Broach, eds.). Cold Spring Harbor Press, New York.
  223. Olesen, J., Fikes, J., and Guarente, L. (1991). The fission yeast homolog of budding yeast HAP2 reveals selective and stringent conservation of the small “essential core” protein domain. Mol. Cell. Biol. 11: 611-619.
  224. Becker, D.M., Fikes, J.D., and Guarente, L. (1991). A cDNA encoding a human CCAAT-binding protein cloned by functional complementation in yeast. Proc. Natl. Acad. Sci. USA 88: 1968-1972.
  225. Becker, D.M., and Guarente, L. (1991). High-efficiency transformation of yeast by electroporation. Meth. Enz. 194: 182-187.
  226. Schneider, J.C., and Guarente, L. (1991). Regulation of the yeast CYT1 gene encoding Cytochrome C1 by HAP1 and HAP2/3/4. Mol. Cell. Biol. 11: 4934-4942.
  227. Schneider, J.C., and Guarente, L. (1991). Vectors for expression of cloned genes in yeast: regulation, overproduction and underproduction. Meth. Enz. 194: 373-388.
  228. Berger, S.L., Cress, W.D., Cress, A., Treizenberg, S.J., and Guarente, L. (1990). Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: Evidence for transcriptional adaptors. Cell 61: 1199-1208.
  229. Fikes, J.D., Becker, D.M., Winston, F., and Guarente, L. (1990). Striking conservation of TFIID in Schizosaccharomyces pombe and Saccharomyces cerevisiae. Nature 346: 291-294.
  230. Olesen, J.T., and Guarente, L. (1990). The HAP2 subunit of yeast CCAAT transcriptional activator contains adjacent domains for subunit association and DNA recognition: Model for the HAP2/3/4 complex. Genes and Devel. 4: 1714-1729.
  231. Kim, K. S., Pfeifer, K., Powell, L., and Guarente, L. (1990). Internal deletions in the yeast activator HAP1 have opposite effects at two sequence elements. Proc. Natl. Acad. Sci. USA 87: 4524-4528.
  232. Haldi, M., and Guarente, L. (1989). N-terminal deletions of a mitochondrial signal sequence in yeast. Targeting information of d-aminolevulinate synthase is encoded in non-overlapping regions. J. Biol. Chem. 264: 17107-17112.
  233. Hahn, S., Buratowski, S., Sharp, P., and Guarente, L. (1989) Isolation of the gene encoding the yeast TATA-binding protein TFIID: a gene identical to the SPT15 Suppressor of TY element insertions. Cell 58: 1173-1181.
  234. Kim, K. S., and Guarente, L. (1989). Mutations in the zinc finger DNA binding domain of a yeast activator alter activation of the transcriptional machinery. Nature 342: 200-203.
  235. Hahn, S., Buratowski, S., Sharp, P., and Guarente, L. (1989). Identification of a yeast protein homologous in function to the mammalian general transcription factor TF II A. EMBO J. 8: 3379-3382.
  236. Hahn, S., Buratowski, S., Sharp, P., and Guarente, L. (1989). Yeast TATA binding protein TF II D binds to TATA elements with both consensus and nonconsensus DNA sequences. Proc. Natl. Acad. Sci. USA 86: 5718-5722.
  237. Forsburg, S., and Guarente, L. (1989b). Identification and characterization of HAP4, a third component in the CCAAT-bound HAP2/3 heteromer. Genes and Devel. 3: 1166-1178.
  238. Forsburg, S. L., and Guarente, L. (1989a). Communication between mitochondria and the nucleus in regulation of cytochrome genes in the yeast Saccharomyces cerevisiae. Ann. Rev. Cell Biol. 5: l53-180.
  239. Elledge, S. J., Sugiono, P., Guarente, L., and Davis, R. W. (1989). A genetic selection for genes encoding sequence-specific DNA-binding proteins. Proc. Natl. Acad. Sci. USA 86: 3689-3693.
  240. Buratowski, S., Hahn, S., Guarente, L., and Sharp, P. (1989). Five intermediate complexes in transcription initiation by RNA polymerase II. Cell 56: 549-561.
  241. Osborne, B., and Guarente, L. (1989). Mutational analysis of a yeast transcriptional terminator. Proc. Natl. Acad. USA, 86: 4097-4101.
  242. Pfeifer, K., Kim, K. S., Kogan, S., and Guarente, L. (1989). Functional dissection and sequence of yeast transcriptional activator HAP1. Cell 56: 291-301.
  243. Zagorec, M., Bahler, J., Treich, I., Keng,T., Guarente, L., and Labbe-bois, R. (1988). Isolation, sequence and regulation by oxygen of the yeast HEM13 gene coding for coproporphyrinogen oxidase. J. Biol. Chem. 263: 9718-9724.
  244. Buratowski, S., Hahn, S., Sharp, P., and Guarente, L. (1988). Function of a yeast TATA element-binding protein in a mammalian transcription system. Nature 334: 37-42.
  245. Kispal, G., Rosenkrantz, M., Guarente, L., and Srere, P. (1988). Metabolic changes in Saccharomyces cerevisiae strains lacking citrate synthase. J. Biol. Chem. 263: 11145-11149.
  246. Osborne, B., and Guarente, L. (1988). Transcription by RNA polymerase II induces changes of DNA topology in yeast. Genes and Development 2: 766-772.
  247. Guarente, L. (1988). UASs and Enhancers: Common mechanism of transcriptional activation in yeast and mammals. Cell 52: 303-305.
  248. Chodosh, L., Olesen, J., Hahn, S., Baldwin, A., Guarente, L., and Sharp, P. (1988). A yeast and a human CCAAT-binding protein have heterologous subunits that are functionally interchangeable. Cell 53: 25-35.
  249. Hahn, S., and Guarente, L. (1988). Yeast HAP2 and HAP3: Transcription activators in a heteromeric complex. Science 240: 317-321.
  250. Forsburg, S., and Guarente, L. (1988). Mutational analysis of the upstream activation sequence 2 of the CYC1 gene of Saccharomyces cerevisiae: a HAP2-HAP3-responsive site. Mol. Cell. Biol. 8: 647-654.
  251. Hahn, S., Pinkham, J., Wei, R., Miller, R., and Guarente, L. (1988). Isolation and characterization of the HAP3 gene of Saccharomyces cerevisiae: A second regulatory gene required for activity of the CYC1 UAS2 element. Mol. Cell. Biol. 8: 655-663.
  252. Olesen, J., Hahn, S., and Guarente, L. (1987). Yeast HAP2 and hap3 activators both bind to the CYC1 activation site, UAS2, in an interdependent manner. Cell 51: 953-961.
  253. Keng, T., and Guarente, L. (1987). Multiple regulatory systems result in constitutive expression of the yeast HEM1 gene. Proc. Natl. Acad. Sci. USA 84: 9113-9117.
  254. Guarente, L. (1987). Regulatory proteins in yeast. Ann. Rev. Gen. 21: 425-452.
  255. Prezant, T., Pfeifer, K., and Guarente, L. (1987). Organization of the regulatory region of the yeast CYC7 gene: multiple factors are involved in regulation. Mol. Cell. Biol. 7: 3252-3259.
  256. Greene, J., and Guarente, L. (1987). Subcloning. In: Methods in Enzymology, 152, pp.512-521.
  257. Schneider, J., and Guarente, L. (1987). The unstranslated leader of nuclear COX4 gene of Saccharomyces cerevisiae contains an intron. Nuc. Acids Res. 15: 3515-3529.
  258. Pfeifer, K., Prezant, T., and Guarente, L. (1987b). Yeast HAP1 activator binds to two upstream activation sites of different sequences. Cell 49: 19-27.
  259. Pfeifer, K., Arcangioli, B., and Guarente, L. (1987a). Yeast HAP1 activation competes with the factor RC2 for binding to the upstream activation site UAS1 of the CYC1 gene. Cell 49: 9-18.
  260. Pinkham, J., Olesen, J., and Guarente, L. (1987). Sequence and nuclear localization of the yeast HAP2 protein, an activator of transcription. Mol. Cell. Biol. 7: 578-585.
  261. Lalonde, B., Arcangioli, B., and Guarente, L. (1986). A single upstream activation site, UAS1, has two distinct regions essential for its activity. Mol. Cell. Biol. 6: 4690-4696.
  262. Guarente, L. (1986). Recent progress in studies of CYC1 transcriptional regulation. In: Biological Research on Industrial Yeasts Vol. III. CRC Press, Inc., Florida.
  263. Guarente, L. (1986). Regulation of the yeast CYC1 gene. In: Extrachromosomal Elements in Lower Eukaryotes (Wickner, R.B., A. Hinnebusch, A.M. Lambowitz, I.C. Gunsalus and A. Hallaender, eds.). Plenum Press, New York, Basic Life Sciences, 40: 513-518.
  264. Rosenkrantz, M., Tausif, A., Kim, K. S., Clark, B., Srere, P., and Guarente, L. (1986). Mitochondrial and non-mitochondrial citrate synthases in yeast are encoded by distinct homologous genes. Mol. Cell. Biol. 6: 4509-4515.
  265. Wei, R., Wilkinson, H., Pfeifer, K., Schneider, C. J., Young, R., and Guarente, L. (1986). Two or more copies of Drosophila heat shock consensus serve to activate transcription in yeast. Nucl. Acids Res. 14: 8183-8188.
  266. Verdiere, J., Creusot, F., Guarente, L., and Slonimski, P. P. (1986). The overproducing CYP1 and the underproducing HAP1 mutations are alleles of the same gene which regulates in trans the expression of the structural genes encoding iso-cytochromes. C. Current Genetics 10: 339-342.
  267. Kim, K. S., Rosenkranz, M., and Guarente, L. (1986). Saccharomyces cerevisiae contains two functional citrate synthase genes. Mol. Cell. Biol. 6: 1936-1942.
  268. Keng, T., Alani, E., and Guarente, L. (1986). Amino-terminal fragment of delta-aminolevulinate synthase can direct beta-galactosidase to the mitochondrial matrix. Mol. Cell. Biol. 6: 355-364.
  269. Hahn, S., Hoar, E., and Guarente, L. (1985). Each of three “TATA elements” specifies a subset of the initiation sites of the CYC1 promoter of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 82: 8562-8566.
  270. Pinkham, J., and Guarente, L. (1985). Cloning and molecular analysis of the HAP2 locus: a global regulator of respiratory genes in Saccharomyces cerevisiae. Mol. Cell. Biol. 5: 3410-3416.
  271. Guarente, L. (1985). Regulation of the yeast CYC1 gene. In: Microbiology. American Society for Microbiology, pp. 37383.
  272. Guarente, L. (1985). Yeast UASs as coordinators of gene expression. In: Eukaryotic Transcription. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  273. Guarente, L. (1984). Regulation of cytochrome-encoding genes in Saccharomyces cerevisiae. In: Proceedings of the Developmental Society Symposium (June, 1984).
  274. Guarente, L., and Hoar, E. (1984). The upstream activation sites of the CYC1 gene of Saccharomyces cerevisiae are active when inverted but not when placed downstream of the TATA box. Proc. Natl. Acad. Sci. USA 81: 7860-7864.
  275. Guarente, L. (1984). Yeast promoters: Positive and negative elements. Cell 36: 799-800.
  276. Guarente, L., Lalonde, B., Gifford, P., and Alani, E. (1984). Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of Saccharomyces cerevisiae. Cell 36: 503-511.
  277. Guarente, L. (1984). Use of gene fusions to study biological problems. In: Genetic Engineering, Principles and Methods, Vol. 6 (J. K. Setlow and A. Hollaender, eds.) Plenum Press, New York. pp. 233-251.
  278. Mason, T., Little, H. N., Van Sickle, C., and Guarente, L. (1984). The role of heme and oxygen in the regulation of mitochondrial cytochromes. In: Nucleo-cytoplasmic Interactions (Wolf, Schweyen, and Kandewitz, eds.) de Gruyter.
  279. Guarente, L. (1983). Transcription of the yeast CYC1 gene is activated by heme via an upstream activation site. In: Enhancers and Eukaryotic Gene Expression (Y. Gluzman and T. Shent, eds.). Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. pp. 190-193.
  280. Michaelis, S., Guarente, L., Inouye, H., and Beckwith, J. (1983). In vitro construction and characterization of phoA-lacZ gene fusions in Escherichia coli. J. Bacteriol. 154: 356-365.
  281. Guarente, L., and Mason, T. (1983). Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site. Cell 32: 1279-1286.
  282. Guarente, L. (1983). Yeast promoter and lacZ fusions designed to study expression of cloned genes in yeast. Meth. Enz. 101: 181-191.
  283. Guarente, L., Yocum, R., and Gifford, P. (1982). A GAL10-CYC1 hybrid promoter identifies the GAL4 regulatory region as an upstream site. Proc. Natl. Acad. Sci. USA 79: 7410-7414.
  284. Gray, M., Colot, H., Guarente, L., and Rosbash, M. (1982). ORF cloning: the identification, cloning, and expression of open reading frame DNA. Proc. Natl. Acad. Sci. USA 79: 6598-6602.
  285. Guarente, L., Nye, J.,Hoschild, A., and Ptashne, M. (1982). A mutant repressor of phage lambda with a specific defect in its positive control function. Proc. Natl. Acad. Sci. USA 79: 2199-2203.
  286. Guarente, L., and Ptashne, M. (1981). Fusions of Escherichia coli lacZ to the cytochrome c gene of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 78: 2199-2203.
  287. Guarente, L., Roberts, T. M., and Ptashne, M. (1980). A technique for expressing eukaryotic genes in bacteria. Science 209: 1428-1430.
  288. Taniguchi, T., Guarente, L., Roberts, T. M., Kimelman, D., Douhan III, J., and Ptashne, M. (1980). Expression of the human fibroblast interferon gene in Escherichia coli. Proc. Natl. Acad. Sci. USA 77: 5230-5233.
  289. Guarente, L., Isberg, R., Syvanen, M. and Silhavy, T. (1980). The conferral of transposable properties to a chromosomal gene in Escherichia coli. J. Mol. Biol. 141: 235-248.
  290. Guarente, L., Lauer, G., Roberts, T. M., and Ptashne, M., (1980). Improved methods for maximizing expression of a cloned gene: a bacterium that synthesized rabbit beta-globin. Cell 20: 543-553.
  291. Wu, A., Chapman, A., Platt, T., Guarente, L., and Beckwith, J. (1980). Deletions of distal sequences affect termination of transcription at the end of the tryptophan operon in Escherichia coli. Cell 19: 829-836.
  292. Guarente, L., Beckwith, J., Wu, A., and Platt, T. (1979). A_mutation distal to the messenger RNA endpoint reduced transcription termination in the tryptophan operon in Escherichia coli. J. Mol. Biol. 133: 189-197.
  293. Silhavy, T., Brickman, E., Bassford, P., Casadaban, M., Shuman, A., Schwartz, V., Guarente, L., Schwartz, M., and Beckwith, J. (1979). Structure of the malB region in Escherichia coli K12. II. Genetic map of the malE, F, G operon. Mol. Gen. Genet. 174: 249-259.
  294. Guarente, L. (1979). Restoration of termination by RNA polymerase mutations is rho allele specific. J. Mol. Biol. 129: 295-304.
  295. Bassford, P., Beckwith, J., Berman, M., Brickman, E., Casadaban, M., Guarente, L.,Saint-Girons, I., Sarthy, A., Schwartz, N., Shuman, H., and Silhavy, T. (1978). Genetic fusions of the lac operon: a new approach to the study of biological processes. In: The Operon (J.H. Miller and W.S. Reznikoff, eds.). Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
  296. Guarente, L., and Beckwith, J. (1978). A mutant RNA polymerase of E. coli which terminates transcription in strains making defective rho factor. Proc. Natl. Acad. Sci. USA 75: 294-297.
  297. Guarente, L., Mitchell, D., and Beckwith, J. (1977). Transcription termination at the end of the tryptophan operon of E. coli. J. Mol. Biol. 112: 423-436.